What Are The Classifications Of Pharmaceutical Intermediates?

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Conventionally, most of the intermediates needed for pharmaceutical production were originally produced by pharmaceutical companies. However, in recent years, with the deepening of social division of labor and the progress of production technology, the production of some pharmaceutical intermediates has gradually been separated from the production of pharmaceutical companies and transferred to chemical companies for production. From an international perspective, pharmaceutical intermediates have now become a major industry in the international chemical industry.

What are the common pharmaceutical intermediates? Pharmaceutical intermediates refer to chemical raw materials or chemical products used in the process of drug synthesis. Judging from the development history of my country's pharmaceutical intermediate industry, after nearly 30 years of development, pharmaceutical intermediates have developed from a small branch of the chemical industry to an emerging industry with an output value of several billion yuan, and its market competition has become increasingly fierce. The following editor will introduce you to several common pharmaceutical intermediates:


N-benzyl-N-methylethanolamine is an important pharmaceutical intermediate, which can synthesize anti-asthma and anti-allergic drugs, anti-hypertensive drug nicardipine and some new drugs for the treatment of cardiovascular diseases; in addition, it can also synthesize pesticides, herbicides and plants. Bactericide and metal preservative, etc.

4,4’-Dimethoxymethyl acetoacetate

4,4'-Dimethoxyacetoacetate is an important intermediate for the treatment of cardiovascular and cerebrovascular diseases, nilvadipine. It is currently the leading treatment for cardiovascular and cerebrovascular diseases in the international market, and it has not been produced in China. Using glyoxylic acid as raw material and trimethyl orthoformate in the presence of concentrated sulfuric acid to synthesize methyl dimethoxyacetate, the latter reacts with methyl acetate and sodium methoxide to obtain methyl 4,4'-dimethoxyacetoacetate ester.

α-Methylene Cyclic Ketone

α-Methylene cyclic ketone is the active center of many anti-cancer active drugs. It contains α, β-unsaturated ketone structure, which is a hidden group of anti-cancer active groups, and has become important for the synthesis of many important cyclic anti-cancer drugs. Intermediate.


4-Propylthio-o-phenylenediamine is a key intermediate of a high-efficiency broad-spectrum insect repellent drug albendazole. Albendazole is a new drug that was only marketed in the late 1980s. It has low toxicity to humans and animals and is a benzo Imidazoles are the strongest Chinese medicine.